Ecofriendly Synthesis Of Metformin Loaded Silver Nanoparticles Using Natural Polymers And Synthesised Starch As Stabilizing Agents

Project and Seminar Material for Pharmaceutical Science

Project and Seminar Material for Pharmaceutical Science


Abstract


Metformin loaded silver nanoparticles were synthesized using ecofriendly method with extract of Azadiractha indica as reducing agent and two natural polymers; guar gum and xanthan gum, Sodium alginate, and a semi- synthetic polymer (AMS) as stabilizing agents. Twelve batches of nanoparticles were synthesized. Nanocomposites synthesized from AMS were designated as AMS 1% NANOmet, AMS3% NANOmet and AMS5% NANOmet. Guar
gum stabilized nanoparticles were designated as GG1% NANOmet, GG3% NANOmet and GG5% NANOmet while Xanthan gum nanocomposites were coded as XG1% NANOmet, XG3% NANOmet and XG5% NANOmet respectively. Sodium alginate stabilized nanocomposites were designated as NaALG1% NANOmet, NaALG3% NANOmet and NaALG5% NANOmet respectively.

The percentage yield of nanocomposites was high with values ranging from 80 % to 99.87 %. The entrapment efficiencies of the samples ranged from 63.06 % to 80.22 % while the loading capacities were in the range of 7.24 % to 24.10%. Differential scanning calorimetry showed there was no interaction between the polymers and metformin. Characterization of the metformin nanocomposites using UV- v is spectroscopy, zeta sizer, scanning electron microscopy (SEM) and polydispersity were performed. The UV-vis spectroscopy showed surface plasmon resonance of 371nm for all the nanocomposites except XG5%NANOmet which had SPR of 335nm.

The mean particle size of GG1%NANOmet was ideal with a value of 188.7nm followed by AMS1%NANOmet (386.7nm). All the batches showed extended and sustained release profile with initial burst effect at the first 30 min of release studies. Release of metformin in SIF was predominantly higher than in SGF. The kinetics of release was mainly zero order for all the nanocomposites with the exception of NaALG5% NANOmet which released the drug by higuchi kinetics. Antimicrobial property of the optimized nanocomposites were similar (P>0.05). Generally, MIC values of the samples against the microorganisms tested ranged from 2500- 5000μg/ml.

In vivo anti hyperglycemic property of the optimized metformin nanocomposite using glucose hyperload model results showed GG5%NANOmet as the optimum batch. At equal doses it produced sustained and consistent significant (p<0.001) decrease in elevated blood glucose level in glucose loaded hyperglycemic rats when compared with metformin and other nanocomposites treated groups.


Ecofriendly Synthesis Of Metformin Loaded Silver Nanoparticles Using Natural Polymers And Synthesised Starch As Stabilizing Agents


Project Material Download

3,000 Naira


The complete material will be sent to you in just 2 steps.

Quick & Simple…


Step One Purchase

Make payment of ₦3,000: through USSD Transfer, Bank Mobile App, ATM Transfer, or POS Transfer to:

Access Bank PlcAccount No.: 0811003731
Name: Samphina Academy
Account Type: Current

Or Click Here to pay with Debit Card

FOR CLIENTS OUTSIDE NIGERIA:
Click Here to pay with Debit Card ($15)
GHANA – Make Payment of 60 GHS to MTN MoMo, 0553978005, Douglas Osabutey 

  PAY WITH CRYPTOCURRENCY


Step Two Purchase

Send the following details through Text Message or WhatsApp Messenger | +234-8143831497

  • Payment Details 
  • Email Address 
  • Ecofriendly Synthesis Of Metformin Loaded Silver Nanoparticles Using Natural Polymers And Synthesised Starch As Stabilizing Agents

The complete material will be sent to your email address after receiving your payment information | T & C Apply


  Contact Our Help Desk


You may also like:

⚠️ Need a different topic? Perform a quick search



Get A Complete Business Plan For Any Business In Nigeria

Business Plan for Businesses in Nigeria

  Business Plans in Nigeria


Ecofriendly Synthesis Of Metformin Loaded Silver Nanoparticles Using Natural Polymers And Synthesised Starch As Stabilizing Agents


Disclaimer

This research material “Ecofriendly Synthesis Of Metformin Loaded Silver Nanoparticles Using Natural Polymers And Synthesised Starch As Stabilizing Agents” is for research purposes and should be used as a guide in developing your research project / seminar work. For no reason should you copy word for word (verbatim) as samphina.com.ng will not be liable for any who copied the material.

The aim of providing this material is to reduce the stress of moving from one school library to another all in the name of searching for research materials. This service is legal because, all institutions permit their students to read previous projects, books, articles or papers while developing their own works. According to Austin Kleon “All creative work builds on what came before”.

samphina.com.ng is only providing this material “Ecofriendly Synthesis Of Metformin Loaded Silver Nanoparticles Using Natural Polymers And Synthesised Starch As Stabilizing Agents” as a reference for your research. The paper should be used as a guide or framework for your own paper. The contents of this paper should be able to help you in generating new ideas and thoughts for your own research. Use it as a guidance purpose only.


How to defend your research work


This is a general guide on how to defend your research work:

1. Prepare For Questions:

If you are preparing for questions that may be asked during your defense, then your answers will flow smoothly and effectively. This will prove your knowledge on the subject e.g “Ecofriendly Synthesis Of Metformin Loaded Silver Nanoparticles Using Natural Polymers And Synthesised Starch As Stabilizing Agents“, and strengthening your argument. Ask friends and family, read your work for them to listen to your presentation, and write down questions. You may be lucky the panel will ask you those you have already prepared on.

2. Strong Summary:

Summarizing your chapters will help keep your audience focused because it is easy for a mind to drift, so providing summaries will ensure your panel will follow along, even if they lose focus for a brief moment. Visual aides, such as graphs and power-point presentations can be very helpful. If you are going to use these, make sure you will practice your presentation with them.

3. Be Confident in Your Research Work:

Not knowing your topic “Ecofriendly Synthesis Of Metformin Loaded Silver Nanoparticles Using Natural Polymers And Synthesised Starch As Stabilizing Agents” inside out will cause you to struggle and ultimately fail with your defense. You need to know the subject from every angle to ensure you are fully prepared for any question that may come your way.

4. Conclusion:

Reinforce your findings to conclude your defense. The finale of your presentation should focus on proving the work that has been done. You may need to recap on what has changed and remained unchanged, if is necessary.

5 . Listen:

Before you get defensive or recite a particular answer, make sure you truly understand the question being asked. Being a good listener is an important quality, because providing an inaccurate or off-topic answer will also weaken the validity of your paper.

Samphina Academy

Samphina Academy is an Online Educational Resource Center that is aimed at providing students with quality information and materials to aid them in succeeding in their academic pursuit.